The study was conducted over a 6 month period. The frequency, severity and duration of worsening symptoms diminished significantly when compared with the group receiving the placebo. Improvement of lung function, reduction in shortness of breath and general quality of life was statistically significant when compared with the placebo group.
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Respiratory Research 2009:
These collective findings underline that cineole not only reduces exacerbation rate but also provides clinical benefits as manifested by improved airflow obstruction, reduced severity of dyspnea and improvement of health status. Therefore, cineole can provide a useful treatment option for symptomatic patients with COPD in addition to treatment according to the guidelines. These results have to be seen in context with socio-economic aspects. As COPD is an extremely costly disease and a cause of major financial and social burden concomitant therapy with cineole can be recommended, especially due to the lack of relevant side effects and relatively low cost. The results of our study provide good evidence that cineole will show benefits as additional therapeutic regimen in patients with COPD. These findings correspond to the interpretation of the efficacy-study with Carbocysteine but not with Acetylcysteine, because this medication did not show a significant reduction of exacerbations [22,23] .